On whitetails? Use a ballistic tip Hands down. I think its one of the best if not the best deer bullet out there, and for a whitetail you don't need a bonded bullet. For elk, use an accubond, but I've used ballistic tips on three elk all with one shot kills. You have to be sure and shoot behind the shoulder, as to not hit bone, oh and all three elk were complete pass throughs...But you were asking about whitetails so use the ballistic tip, sorry everybody got off on elk for some reason...

No, there is not a noticable difference on whitetails! Whitetails aren't tough and either will knock them on their cans with great aplumb. Nothing against Nosler, they are great bullets but you don't need a premium bullet for deer either; I have used Hornadys for over 40 years and have NEVER had a bullet problem. In all that time I have only recovered one rifle bullet from a deer out of my 25-06. That was end-to-end at 200 yards through pelvis, three ribs on the left and three ribs on the right and through the heart and out the brisket. the bullet was hanging in the hide in the front of the chest but I recovered it. They just don't get any deader than that!