.270, they say it can take and big game animal in America and its not overkill for really anything but varmints, mice, and ants.

.270, works for all deer.

270 is all you need for most game in north america. 30-30, 30-06, and 270 are the most popular deer hunting rounds out there and they on the top of the list for a reason. i personally use a 7mm-08, but i just like to be different, haha.

for deer it would be the 243. win hands down

A 300 win mag is ok for a elk gun but I have seen quite a mess done with a 300 win mag on a deer unless it is a long shot. I think a 300 win mag is an over rated bullet when you really do the science.

From your choices in the original question, the .270 would be my choice, although none of those is among the many hunting rifles that I own. The .243 is a boy's rifle and the .300 Win Mag is way overkill for deer. You can get a lot of bloodshot meat from any of the three high velocity rounds, particularly the .300 Win Mag.

My personal preference is the .257 Roberts, .308 Win, or .300 Savage for strictly deer, but that was not what you asked! Just me.

it depends on what your comfortable with. try them all, if you can and pick what fits you best. i deer hunt with a .243 . i like how light weight it is it's easy to handle in thick brush and has taken many whitetail

Given the three choices - .270 would be the one.

270 or 243...300 would be a little over kill

a .270. But if I had just one gun I would go with the 300 win mag because it works great on elk.

.270 any day depending on where you hunt and your rifle and optics

Interesting that more pre-64 Winchester Model 70s, the Rifleman's Rifle, were chambered in .243 Win than any other caliber. .308 Win was second.

Howabout 280 Remington, 6mm Remington, 7x57mm Mauser, 308 Winchester, 30-06 Springfield, 25-06........ Any of those would be great for deer. But I still prefer to use a 44 Remington mag lever gun.