I'm talking all-time, if-you-could-only-fish-one-fly-for-the-rest-of-your-life favorite fly.
For me, it's the Ray Charles, which is a scud pattern made with nothing more than an ostrich plume and a strip of pearl tinsel. I discovered it in a fly shop in Montana. When I asked why it's called a Ray Charles, the lady at the shop said, "Because even a blind man can catch fish with it."
She was right. I've been duping trout with it like crazy ever since.