There are a few exceptions: My New Ultra Light Arms 6.5 Swede, for which I interchange 130-grain Swift Scirocco 2 handloads and Norma 156-grain Oryx factory loads. The first is for everything. The second is for big animals at close range only. Up to 100 yards, they shoot literally through the same hole, and you can’t mistake one bullet for another.
Montana Rifles .30/06. My everything handload is a 180-grain Swift Scirocco 2 at 2,850 fps. For big stuff at ranges under 250 yards, I use Swift 200-grain A-Frames, a truly fearsome bullet that will do most of what a .338 will do and kick you a lot less in the process. Again, the one bullet doesn’t look anything like the other.