25-06

I would take the .264 Win Mag.

To do this with any caliber you would have to give up some animals.

It's a toss up between the .270 and the .30-06.

I'm stocking up on 338 Win Mag

.30-06 no contest

300 Win Mag, if I can ever get it back from my brother!

7 mm rem. mag

Depends on where you are from, I'm from Montana and I use a 300 mag. It's a tad bit powerful for deer, but for elk it's great. I think a 270 is also a good gun!

30-06

I would probably have to pick the .306, especially after remington made a bunch of new loads to better suite hunters. They know have catridges in .306 that can be used on deer all the way up to big game which makes it very versatile.

I THINK I could kill anything I wanted to with a 25-06 but I KNOW I could kill anything I ever needed to with a 338 win mag. I am confident with one and supremely confident with the other, the other is just a little harder on the shoulder.

30/06 or a .300

Define big game. North America + plains game, .30-06
Anything more, i.e. big-ass game, minigun.

.45/70. From the wild west, to across the ocean to shoot the other kind of buffalo. But not without first hanging out in the Vermont deer woods for a while, or making a pit stop in Washington for elk and some Garrett Cartridges.

45/70

One gun Mr. Cooper. mine would have to be the .30-06, because range of ammo sizes,availability, and lasty but not least knock down power.

30-06

A .375 H&H, but I don't own one. Pachyderms to pronghorns can be handled with a .375 but I would rather have a choice. Why compromise? A .223 and a .500 N.E.? a dozen stops in between. Traditional lever action carbines, tack driving bean field rifles, English double rifles, 1903 Springfield sporters, black rifles, vanilla bolt action workhorses, air weight mountain rifles, engraved Teutonic single shots. Too many choices! Enough of this sillyness, just grab the 30/06 and head out back to look for a black bear. Shoot the .458 some more before you go back to Africa.

30-06 fo sho.