All the muzzle brakes I've tried have been extremely effective. That's the good news. The bad news is that they direct muzzle blast off to the side or back toward you, and the resulting thunderclap will leave you screaming on your knees. I think that if a .416 Remington is made to weigh enough (around 11 pounds, with scope), you shouldn't need a muzzle brake. But if you want one installed, I suggest you contact custom gunsmith David Gentry (www.gentrycustom.com). He makes and installs a very good one.