The .308 should work fine with the right ammunition, but your suggested load has me puzzled. Nosler doesn't make a roundnose 180-grain Partition. Are you thinking of their 180-grain Protected Point with the flat tip? Also, while the Nosler Reloading Manual Number Four lists 44 grains of IMR4064 as the top load for their 180-grain bullets, the muzzle velocity of 2718 fps is taken in a 24-inch barrel. You'll lose at least 100 fps from the shorter barrels of your rifles, maybe more, so the 300-yard velocity will be 1900 fps or less, the absolute minimum for expansion with Partitions. This bullet is designed especially for the .300 Winchester Magnum, not the .308, so it may not even expand much at 1900 fps. I'd suggest their 165-grain Partition Spitzer instead, using 44 grains of Alliant's Reloder 15. This will get you about 100 fps more muzzle velocity, and the pointed tip will retain more velocity and energy too, arriving at 300 yards traveling at about 2100 fps. Expansion will be certain and trajectory flatter. I've used this bullet a lot, and it works great.