What I agree with is the buffalo. It'll kill them, but it won't impress them. The first one I ever shot was at 15 yards, right where the dewlap runs into the chest, with a 300-grain screw-machine Nosler Partition. He ran off a little ways to think things over while I continued to pump bullets into him. He was not so much hurt as aggrieved. Finally he collapsed under the sheer weight of the lead. The next three followed the same pattern, and that was the last time I used a .375 H&H on old nyati. Since then, I've shot them with a .416 Remington, .458 Winchester, and .458 Lott, and all three did much, much better.