Bourjaily: A Self Defense Poll

I was at the local sporting goods store buying powder the other day when I overheard two guys looking at the pistol ammo.

"$40 bucks!" exclaimed one, reading the price tag on a box.

"It's premium self-defense ammunition," explained the other. "You get one shot stops."

"Forget that. I'd rather shoot someone twice than pay forty dollars," said the first.

That qualifies as Gun Nut Quote of the Day for sure, but does it make sense?

Self-defense handguns are out of my area so let me put this to all of you in the form of a poll question: pay for the premium stuff or shoot an assailant twice?* If possible, explain your answer with references to specific calibers and/or bullets. Let's hear it.

*"Both" is also an acceptable answer and perhaps the best choice.