From what I’ve seen, there are more Alaska bear guides carrying .375s than anything else. The ammo comes loaded with bullets ranging from 260 grains, which is suitable for ground squirrels, to 300 grains, which is the only weight I would consider. The .375, because of its considerable case taper and gentle shoulder angle, can be made to feed like greased asparagus in a properly set up rifle. This can be of considerable importance. If you want factory ammo, try the Federal loaded with 300-grain Trophy Bonded bullets. For handloaders, the 300-grain Swift A-Frame is the way to go.